P53 Mutation Cancer Cell Lines

P53 gene structure and chromosome 17p alleles were studied in the three human prostate cancer cell lines lncap du 145 and pc 3.

P53 mutation cancer cell lines.

Ht 29 caco 2 and sw480 contain mutated p53 were used as the panels in this study to. Analysis of p53 mutation status in human cancer cell lines. Brain cancer cell lines. Several fundamental features of wild type and mutant proteins and their modifications are reviewed as well as animal models and clinical aspects such as recommendations for patient care.

This special issue on tp53 propels the tp53 gene into the post genomic era. Bladder cancer cell lines. This panel combines wild type p53 cell lines with mutant p53 cell lines that carry hotspot mutations in one of the following codons. The id cards include cell line data such as cancer type and atcc number when available as well as some specific information on potential misidentifications changes of identity or shared origins.

Colorectal cancer cell lines. A special issue of human mutation has been released. The tp53 gene network in the post genomic era. The colon cancer p53 hotspot mutation cell panel atcc no.

The hanbook of p53 mutation in cell lines. A paradigm for cell line cross contamination. Cell lines by gene mutation tumor cell lines become more powerful tools for cancer research and drug discovery when the genetic abnormalities that drive their phenotype are known. The p53 mutations in cell lines compendium the current version includes 2 000 and 500 cell lines with mutant tp53 and wild type tp53 respectively.

Breast cancer cell lines. Hct 116 cells contain wild type p53. One strain lncap gw had a mutation in one of two alleles at position 273 arg. The nci 60 panel.

Tcp 2020 is composed of six select cell lines derived from colon cancer. P53 mutations in cell lines. Atcc now offers our reliable authenticated tumor cell lines annotated with gene mutation infor mation from the sanger institute cosmic database. Cell lines with a controversial p53 status.

Since then a large number of publications have demonstrated many gofs in numerous cell lines with a variety of p53 mutations summarized in table 1 the gof acquired by mutant p53 is further supported by the finding that patients carrying a tp53 missense mutation leading to expression of a. Human colon cancer cell lines with varied molecular characteristics eg. Esophageal cancer cell lines. 175 245 248 or 273.

Knowledgebase and statistical tools for the analysis of tp53 gene mutations in human cancers. Epub 2008 may 11. Our laboratory has two separate culture lines of the lncap human prostate cancer cells.